[Todos] Seminario de Química Orgánica (Jueves 29, 11 hs!)

[Carla Marino]

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SEMINARIO DE QUÍMICA ORGÁNICA 

http://www.qo.fcen.uba.ar/Cursos/semin.htm

Aula Dr. Venancio Deulofeu

Departamento de Química Orgánica

Ciudad Universitaria, Pab. II, Piso 3

 


Jueves 29 de Junio, 11 hs



Dr. Marcos L. Sznaidman

Director of Chemistry, Xsira Pharmaceuticals, Research Triangle Park, North Carolina, USA 





NOVEL SELECTIVE SMALL MOLECULE AGONISTS FOR PPAR d.

The peroxisome proliferators-activated receptors (PPARs) are dietary lipid sensors that regulate fatty acid and carbohydrate metabolism.  There are three known PPAR receptors: alpha, gamma and delta.  Activation of PPAR alpha results in hypolipidemic effects, activation of PPAR gamma results in antidiabetic effects.  By contrast, the therapeutic potential of PPAR delta receptor is unknown, due in part to the lack of selective ligands. This presentation is going to show the use of combinatorial chemistry and structure-based design that resulted in the development of a potent and selective PPAR delta agonist: GW501516.   This compound increases HDL (good cholesterol) and reduces the levels of LDL (bad cholesterol), fasting triglycerides, and fasting insulin.  GW501516 is now in Phase II clinical trials in USA for the treatment of lipid metabolism disorder



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