[Todos] Seminario de Química Orgánica - Miércoles 10 de octubre - 14 horas

[Sergio M. Bonesi]

Horario de Seminario: 14 horas

SEMINARIO DE QUÍMICA ORGÁNICA 

http://www.qo.fcen.uba.ar/Cursos/semin.htm

Miércoles 10 de octubre, 14 hs. Aula Dr. Venancio Deulofeu, Departamento de Química Orgánica

Ciudad Universitaria, Pab. II, Piso 3

 

Dr. Chryssostomos Chatgilialoglu

 

ISOF, Consiglio Nazionale delle Ricerche, Bologna, Italy.

 

One-electron reduction of 8-bromopurine nucleosides

and excess electron transfer through DNA

 

 

The reactions of hydrated electrons (eaq-) with a variety of 8-bromopurine nucleosides have been investigated by radiolytic methods coupled with product studies, and addressed computationally by means of DFT-B3LYP calculations. A different behavior is observed for the defferent purines. The reactions of eaq- with a variety of single- and double-strand oligonucleotides as well as four stranded quadruplex complexes that contain 8-bromopurine nucleotides have been studied. Our results demonstrated that some of these bromo-derivatives are very effective in excess electron transfer and they can behave as an ultimate sink for electrons due to the Br- ejection.

 

References.

1)  Chatgilialoglu, C.; Guerra, M.; Mulazzani, Q. G. J. Am. Chem. Soc. 2003, 125, 3839-3848.

2)  Chatgilialoglu, C.; Duca, M.; Ferreri, C.; Guerra, M.; Ioele, M.; Mulazzani, Q. G.; Strittmatter, H.; Giese, B. Chem. Eur. J. 2004, 10, 1249-1255.

3)  De Champdoré,  M.; De Napoli, L.; Montesarchio, D.; Piccialli, G.; Caminal C.; Mulazzani, Q. G.; Navacchia,  M. L.; Chatgilialoglu, C. Chem. Commun. 2004, 1756-1757.

4)  Chatgilialoglu, C.; Caminal C.; Guerra, M.; Mulazzani, Q. G. Angew. Chem. Int. Ed. 2005, 44, 6030-6032.

5)  Manetto, A.; Breeger, S.; Chatgilialoglu, C.; Carell, T. Angew. Chem. Int. Ed. 2006, 45, 318-321.

6)  Russo, M.; Jimenez, L. B.; Mulazzani, Q. G.; D'Angelantonio, M.; Guerra, M.; Miranda, M. A.; Chatgilialoglu, C. Chem. Eur. J. 2006, 12, 7684-7693.

7)  Chatgilialoglu, C.; Caminal C.; Altieri, A.; Mulazzani, Q. G.; Vougioukalakis, G. C.; Gimisis, T.; Guerra, M. J. Am. Chem. Soc. 2006, 128, 13796-13805.

8)  Kaloudis, P., D'Angelantonio, M., Gimisis, T., Guerra, M., Mulazzani, Q. G., Chatgilialoglu, C. J. Am. Chem. Soc. 2007 submitted.
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