[Todos] Seminarios conjuntos IFIByNE - DFBMC

[Paula Felman]

>Fecha: jueves 10 de Julio, 13 hs. Aula de seminarios del LFBM
>
>Invitado: Maurizio Fanciulli
>Department of Therapeutic Programs Development, Regina Elena Cancer Institute
>Rome Oncogenomic Center, Regina Elena Cancer Institute
>Rome, Italy
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>Titulo: Che-1, a new effector of checkpoint signalling
>
>Resumen: Che-1 is a RNA polymerase II binding protein involved in the
>transcriptional regulation of E2F target-genes and in cell proliferation.
>Recently, it has been shown that Che-1 accumulates in cells responding to
>genotoxic agents, such as Doxorubicin and ionizing radiations. The DNA
>damage-activated checkpoint kinases ATM and Chk2 interact with and
>phosphorylate Che-1, enhancing its accumulation and stability, and
>promoting Che-1-mediated transcription of p53-responsive genes and of p53
>itself, as evidenced by microarray analysis. This transcriptional response
>is suppressed by expression of a Che-1 mutant lacking ATM and Chk2
>phosphorylation amino acid residues, or by depletion of Che-1 by RNA
>silencing. In addition, chromatin immunoprecipitation analysis has shown
>that Che-1 is released from the E2F-target genes and recruited to the p21
>and p53 promoters after DNA damage. Che-1 contributes to the maintenance of
>the G2/M checkpoint in response to genotoxic stresses. These findings
>identify a new mechanism by which the checkpoint kinases regulate, via the
>novel effector Che-1, the p53 pathway.
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>Host: Arturo Romano
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