[Todos] Seminarios conjuntos IFIByNE - DFBMC- RECORDATORIO Maurizio Fanciulli

[Paula Felman]

>Fecha: jueves 10 de Julio, 13 hs. Aula de seminarios del LFBM
>
>Invitado: Maurizio Fanciulli
>Department of Therapeutic Programs Development, Regina Elena Cancer Institute
>Rome Oncogenomic Center, Regina Elena Cancer Institute
>Rome, Italy
>
>Titulo: Che-1, a new effector of checkpoint signalling
>
>Resumen: Che-1 is a RNA polymerase II binding protein involved in the
>transcriptional regulation of E2F target-genes and in cell proliferation.
>Recently, it has been shown that Che-1 accumulates in cells responding to
>genotoxic agents, such as Doxorubicin and ionizing radiations. The DNA
>damage-activated checkpoint kinases ATM and Chk2 interact with and
>phosphorylate Che-1, enhancing its accumulation and stability, and
>promoting Che-1-mediated transcription of p53-responsive genes and of p53
>itself, as evidenced by microarray analysis. This transcriptional response
>is suppressed by expression of a Che-1 mutant lacking ATM and Chk2
>phosphorylation amino acid residues, or by depletion of Che-1 by RNA
>silencing. In addition, chromatin immunoprecipitation analysis has shown
>that Che-1 is released from the E2F-target genes and recruited to the p21
>and p53 promoters after DNA damage. Che-1 contributes to the maintenance of
>the G2/M checkpoint in response to genotoxic stresses. These findings
>identify a new mechanism by which the checkpoint kinases regulate, via the
>novel effector Che-1, the p53 pathway.

Publicaciones recientes:


- PLoS ONE. 2007 Aug 22;2(1):e774.
Utrophin up-regulation by an artificial transcription factor in transgenic 
mice.
Mattei E, Corbi N, Di Certo MG, Strimpakos G, Severini C, Onori A, Desantis 
A, Libri V, Buontempo S, Floridi A, Fanciulli M, Baban D, Davies KE, 
Passananti C

- J Biol Chem. 2007 Jul 6;282(27):19685-91. Epub 2007 Apr 27.
The prolyl isomerase Pin1 affects Che-1 stability in response to apoptotic 
DNA damage.
De Nicola F, Bruno T, Iezzi S, Di Padova M, Floridi A, Passananti C, Del 
Sal G, Fanciulli M.
- J Biol Chem. 2007 May 18;282(20):15248-57. Epub 2007 Mar 2.
A novel corepressor, BCoR-L1, represses transcription through an 
interaction with CtBP.
Pagan JK, Arnold J, Hanchard KJ, Kumar R, Bruno T, Jones MJ, Richard DJ, 
Forrest A, Spurdle A, Verdin E, Crossley M, Fanciulli M, Chenevix-Trench G, 
Young DB, Khanna KK.
- Cancer Cell. 2006 Dec;10(6):473-86.
Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 
transcription and the G2/M checkpoint.
Bruno T, De Nicola F, Iezzi S, Lecis D, D'Angelo C, Di Padova M, Corbi N, 
Dimiziani L, Zannini L, Jekimovs C, Scarsella M, Porrello A, Chersi A, 
Crescenzi M, Leonetti C, Khanna KK, Soddu S, Floridi A, Passananti C, Delia 
D, Fanciulli M.
- Cancer Cell. 2002 Nov;2(5):387-99.
Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb.
Bruno T, De Angelis R, De Nicola F, Barbato C, Di Padova M, Corbi N, Libri 
V, Benassi B, Mattei E, Chersi A, Soddu S, Floridi A, Passananti C, 
Fanciulli M.




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