[Todos] Seminarios conjuntos DFBMC-IFIByNE- RECORDATORIO

[Paula Felman]

>Fecha: martes 10 de junio, 13hs en el Aula de Seminarios del LFBM
>
>Estimados todos,
>
>Este martes 10 de junio tendremos el agrado de recibir al Dr. Enrico 
>Stefani y la Dra. Ligia Toro. El seminario se llevará acabo en el aula de 
>seminarios del LFBM, 2do piso, Pabellon II de Ciudad Universitaria. Les 
>vamos adelantando la información respectiva:
>
>Enrico Stefani MD, PhD
>Departments of Anesthesiology and Physiology, University of California , 
>Los Angeles
>Distinguished Professor
>Vice Chair of Research, Dept. Anesthesiology
>Director, Division of Molecular Medicine
>Associate Director, Cardiovascular Research Laboratories
>
>Titulo: "Heart Estrogen, Estrogen Receptors and Cardioprotection"
>
>Resumen: Females in the reproductive age are more susceptible to cardiac 
>arrhythmias but they have a lower risk of cardiac disease. We are 
>investigating the mechanism(s) underlying this paradoxical phenomenon.  We 
>discover that heart can locally synthesize estrogen via the conversion of 
>testosterone by aromatase activity.  Heart estrogen is higher in females 
>than in males downregulating K repolarizing currents which explains the 
>higher susceptibility of females to cardiac arrhythmia. At the same time, 
>heart estrogen activates protective signaling cascades reducing the risk 
>of heart failure under stress. Furthermore, estrogen treatment in heart 
>failure by pressure overload rescues the failing heart by reversing the 
>pathological gene expression profile. The role of the various molecules 
>including ion channels and signaling cascades will be discussed in 
>relation to the mechanisms of estrogen induced arrythmogenesis and 
>cardio-protection.
>
>
>Ligia Toro, PhD
>Division of Molecular Medicine, Department of Anesthesiology,
>and Department of Molecular & Medical Pharmacology
>Professor
>University of California , Los Angeles
>Título: "Physiological roles of MaxiK channels"
>
>Resúmen:  MaxiK channels are key regulators of several body functions, 
>including neuronal excitability, uresis, reproduction and blood pressure. 
>Our laboratory has been interested in deciphering basic mechanisms of how 
>MaxiK channels and associated proteins work in concert to regulate blood 
>pressure in health and during aging. I will discuss evidence of new 
>mechanisms by which these ion channels may regulate vasoconstriction 
>including regulation and association with G-protein coupled receptors, 
>long-term genomic regulation by estrogen, and mechanisms of protein 
>targeting.
>
>
>
>
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>
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