[Todos] RECORDATORIO Seminarios HOY Pr. Martin Kupiec - seminarios conjuntos DFBMC-IFIByNE-

[Paula Felman]

>Seminario miercoles 10 de septiembre. 13 hs. Aula del LFBM
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>"Genomic Stability: vertical and horizontal views"
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>Pr. Martin Kupiec,
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>Dept. of Mol. Micro and Biotech.,
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>Tel Aviv University,
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>Ramat Aviv 69978,
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>Israel
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>ABSTACT
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>Telomeres are the specialized DNA-protein structures at the ends of
>eukaryotic chromosomes. Telomeric DNA is synthesized by the enzyme
>telomerase, which copies a short template sequence within its own RNA
>moiety. Telomeres are essential for chromosomal stability and
>integrity, as they prevent chromosome ends from being recognized as
>double strand breaks. In somatic cells, telomerase activity is
>repressed; thus telomeres of all differentiated somatic cells and
>tissues shorten with replicative age and donor age, leading to a
>finite life span. When telomere size becomes shorter than a certain
>threshold length the cells senesce; telomere length regulation can
>thus be considered a tumor-suppressing mechanism. Conversely,
>reactivation of telomerase in cultured cells results in extended life
>span leading to their apparent immortalization. Moreover, it has been
>shown that replenishing telomeres by an activated telomerase is one of
>the few essential steps that a normal human fibroblast cell must take
>on its route to become malignant. Thus, deciphering how telomere
>length is monitored is critical to our understanding of the regulatory
>and signaling mechanisms controlling cellular life span, and will have
>very significant medical implications concerning our ability to
>control aging and to fight cancer.
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>We have carried out a systematic, genome-wide search for genes that,
>when mutated, affect telomere length. Our efforts have uncovered a
>large number (~250) of such genes, which we call TLM (Telomere Length
>Mainrenance) genes. We are currently carrying out small-scale and
>large-scale experiments to organize the TLM genes into functional
>categories. Both vertical (molecular biology) and horizontal (systems
>biology) strategies for understanding telomere length maintenance and
>signal transduction integration will be presented.
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>--
>Alejandro Colman-Lerner