[Todos] VIE 11/11- 11hs Seminario Quimica Organica - C.Oliver Kappe-VIERNES 11/11- 11hs

[Carola Gallo]

SEMINARIO DE QUIMICA ORGANICA 2011

Viernes 11 de noviembre, 11 hs

Aula de Seminario, Departamento de Química Orgánica, FCEyN

 

 Prof. C. Oliver Kappe

 

Christian Doppler Laboratory for Microwave Chemistry and Institute of
Chemistry,

 Karl-Franzens-University Graz, A-8010 Graz, Austria

oliver.kappe en uni-graz.at / www.maos.net

 

Microwave-assisted organic synthesis. From laboratory curiosity to standard
practice in 25 years 

 

 

High-speed microwave synthesis has attracted a considerable amount of
attention in recent years [1-3]. Since the first reports on the use of
microwave heating to accelerate organic chemical transformations by the
groups of Gedye and Giguere/Majetich in 1986, more than 3000 articles have
been published in the area of microwave-assisted organic synthesis (MAOS)
[2]. The initial slow uptake of the technology in the late 1980s and early
1990s has been attributed to its lack of controllability and
reproducibility, coupled with a general lack of understanding of the basics
of microwave dielectric heating. The risks associated with the flammability
of organic solvents in a microwave field and the lack of available systems
for adequate temperature and pressure controls were major concerns. Since
the late 1990s the number of publications related to MAOS has therefore
increased dramatically to a point where it might be assumed that, in a few
years, most chemists will probably use microwave energy to heat chemical
reactions on a laboratory scale. Not only is direct microwave heating able
to reduce chemical reaction times from hours to minutes, but it is also
known to reduce side reactions, increase yields and improve reproducibility.
Therefore, many academic and industrial research groups are already using
MAOS as a forefront technology for rapid reaction optimization, for the
efficient synthesis of new chemical entities, or for discovering and probing
new chemical reactivity. 

This lecture will highlight contributions from our laboratory in the field
of microwave-assisted organic synthesis, in particular as they relate to
heterocyclic synthesis, combinatorial chemistry and the question of scale-up
of microwave-assisted reactions.

 

References

 

[1]  Kappe, C. O. “Controlled microwave heating in modern organic
synthesis.” Angew. Chem. Int. Ed. 2004, 43, 6250.

[2] Kappe, C. O.; Stadler, A. "Microwaves in organic and medicinal
chemistry", Wiley-VCH, 2005.

[3] Kappe, C. O.; Dallinger, D.; Murphree, “Practical Microwave Synthesis
for Organic Chemists”, Wiley-VCH, 2009.

 


 


 


Professor C. Oliver Kappe


 

C. Oliver Kappe is Professor of Organic Chemistry and Director of the
Christian Doppler Laboratory for Microwave Chemistry (CDLMC) at the
University of Graz, Austria. He received his diploma- (1989) and his
doctoral (1992) degrees in organic chemistry from the University of Graz
where he worked with Professor Gert Kollenz on cycloaddition and
rearrangement reactions of acylketenes. After periods of postdoctoral
research work on reactive intermediates and matrix isolation spectroscopy
with Professor Curt Wentrup at the University of Queensland in Brisbane,
Australia (1993-1994) and on synthetic methodology/alkaloid synthesis with
Professor Albert Padwa at Emory University in Atlanta, USA (1994-1996), he
moved back to the University of Graz in 1996 to start his independent
academic career. He obtained his "Habilitation" in 1998 in organic chemistry
and was appointed Associate Professor in 1999. Since 2011 he holds the
position of Professor of "Technology of Organic Synthesis" (Organische
Synthesetechnologie) at the University of Graz. He has spent time as
visiting scientist/professor at e.g. the Scripps Research Institute (La
Jolla, USA, Professor K. Barry Sharpless, 2003), the Toyko Institute of
Technology (Toyko, Japan, Professor T. Takahashi, 2008), the University of
Sassari (Sassari, Italy, 2008), and the Sanford-Burnham Institute for
Medical Research (Orlando, USA, 2010). 

 The co-author of more than 250 publications, his main research interests
have in the past focused on multicomponent reactions, combinatorial
chemistry and the synthesis of biologically active heterocycles. More
recently his research group has been involved with enabling technologies for
synthesis, including microwave and continuous flow chemistry. During the
last few years his lab has authored ~100 original research articles, reviews
and book chapters on microwave-assisted synthesis. His latest book
"Practical Microwave Synthesis for Organic Chemists - Strategies,
Instruments, and Protocols" (co-authored with D. Dallinger and S. S.
Murphree) was published with Wiley-VCH in 2009 and is currently considered
one of the standard reference works in the field. For his innovative work in
microwave chemistry he received the 2004 Prous Science Award from the
European Federation for Medicinal Chemistry and the 2010 Houska Prize in
addition to a number of other awards.

 

C. Oliver Kappe is currently Editor-in-Chief of the Journal of Flow
Chemistry (Akadémiai Kiadó) and a member of the Flow Chemistry Society. He
is also a board member of the International Society of Heterocyclic
Chemistry and The Society of Combinatorial Sciences. In addition he has been
an Editor of the Journal QSAR and Combinatorial Sciences (Wiley-VCH,
2003-2007) and has served/serves on the Editorial/Advisory Boards of the
Journal of Combinatorial Chemistry (ACS), Molecular Diversity (Springer),
ChemMedChem and ChemSusChem (Wiley-VCH), Journal of Heterocyclic Chemistry
(Wiley-VCH) and a number of other journals.

 

 

 

 

 

 

 

 

 

 

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