[Todos] Seminarios conjuntos IFIBYNE-DFBMC- Martes 20 / 9- Damian Refojo

[Paula Felman]

Martes 20 de septiembre 13 Hs. en el aula de seminarios.


Damian Refojo, MD, PhD "Futuro miembro del 
IBioBA-Max Planck Partner Institute" Molecular 
Neurobiology Max Planck Institute of Psychiatry, 
Munich, Germany. Future member of the IBioBA-Max Planck Partner Institute.

Titulo: "Neurotransmitter-specific conditional 
knock-outs o como eliminar un gen in vivo en 
determinados circuitos de neurotransmisores: el 
ejemplo de CRHR1 y sus efectos sobre neurotransmisión y conducta emocional"


Abstract: The corticotropin-releasing hormone 
receptor 1 (CRHR1) critically controls behavioral 
adaptation to stress and is causally linked to 
emotional disorders. Using neurochemical and 
genetic tools we determined that CRHR1 is 
expressed in forebrain glutamatergic and 
GABAergic as well as in midbrain dopaminegic 
neurons and in few serotonergic neurons of the 
raphe. We generated different 
neurotransmitter-specific CRHR1 conditional 
knock-out lines where the CRHR1 gen is deleted in 
specific brain areas and only in glutamatergic, 
GABAergic, dopaminergic and serotonergic neurons 
in vivo. We found that the lack of CRHR1 in 
forebrain glutamatergic circuits reduces anxiety 
and impairs neurotransmission in amygdala and 
hippocampus. Interestingly, selective deletion of 
CRHR1 in midbrain dopaminergic neurons increases 
anxiety-like behavior and reduces dopamine 
release in the prefrontal cortex. These results 
define a new bidirectional model for the role of 
CRHR1 in anxiety and suggest that an imbalance 
between CRHR1-controlled anxiogenic glutamatergic 
and anxiolytic dopaminergic systems might lead to emotional disorders.





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