[Todos] Seminarios conjuntos IFIBYNE-DFBMC - Jueves 20/12 - Manuel de la Mata, PhD.

[Paula Felman]

Jueves 20 de diciembre 13 Hs. en el aula de seminarios.


Título: Mechanistic aspects of miRNA turnover in neurons

Manuel de la Mata, PhD. Friedrich Miescher Institute for Biomedical Research
Basel, Switzerland


Abstract: Increasing evidence indicates that the 
development and function of the nervous system is 
dependent on the spatiotemporal expression of a 
wide repertoire of microRNAs. In dendrites of 
mature neurons, local post-synaptic translation 
seems to have a particularly important role in 
synaptic plasticity and memory. MicroRNAs have 
been shown to regulate local protein translation 
at neuronal dendrites, but little is known about 
its mechanism and functional relevance. 
Intriguingly, the turnover of microRNAs is 
greatly accelerated in neurons relative to most 
cell types, and this property is dependent on 
neuron activity. Here we investigate the role of 
target mRNAs in reciprocally regulating microRNA 
degradation in neurons. Whereas canonically, 
microRNAs silence their target mRNAs, recent 
reports show that target mRNAs may in turn 
influence the decay of their cognate microRNAs. 
We propose that in neurons, where the mutual 
regulation between microRNAs and their targets 
has not yet been explored, this mechanism might 
be important for role of microRNAs in neuronal functions.

Host: ARK