[Todos] Seminarios conjuntos IFIBYNE-DFBMC - Jueves 2/8 Dr. Mariano Soiza Reilly

[Paula Felman]

Jueves 2  de agosto 13.Hs. en el aula de seminarios del LFBM

>Titulo: Unraveling the organization of GABA and 
>glutamate axons in the dorsal raphe nucleus using high-resolution anatomy
>
>Dr. Mariano Soiza Reilly
>
>Anesthesiology Dept., Boston Children’s 
>Hospital, Harvard Medical School, Boston, MA, USA
>
>Resumen: The dorsal raphe nucleus (DR) controls 
>forebrain serotonin (5-HT), regulating stress 
>and emotional states.  Dysregulation of DR 5-HT 
>cells has been implicated in the pathophysiology 
>of mood disorders including depression and 
>anxiety.  DR neurons are regulated by excitatory 
>and inhibitory drives mediated by glutamate and 
>GABA axons arising from different brain 
>regions.  These multiple origins suggest a very 
>complex synaptic neuropil within the 
>DR.  However, we do not know much about how 
>these axons are organized or whether they could 
>be involved in any ordered synaptic 
>arrangements, and this is in part due to 
>technical limitations.  But now we can address 
>these questions using a recently developed 
>high-resolution immunofluorescence technique 
>called Array Tomography.  This technique allows 
>the quantitative analysis of the synaptic 
>neuropil by studying multiple synaptic antigens 
>as well as their relationships to each other in 
>the same volume of tissue.  Our study revealed 
>new synaptic features of DR circuits that may 
>underlie to a direct GABAergic presynaptic 
>regulation of glutamate transmission, supporting 
>a permissive role of GABA on DR’s excitatory drive.
>
>Host: Urbano
>
>--
>Francisco J. Urbano, PhD.
>IFIBYNE-CONICET
>Intendente Güiraldes 2160
>Facultad Ciencias Exactas
>Pabellon 2- Piso 2
>Ciudad Universitaria
>(C1428EGA) Buenos Aires
>ARGENTINA
>Email: <mailto:fjurbano en fbmc.fcen.uba.ar>fjurbano en fbmc.fcen.uba.ar,
><mailto:fran.j.urbano en gmail.com>fran.j.urbano en gmail.com
>Phone: (+54)-11-4576 3368
>Fax: (+54)-11-4576 3321
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