[Todos] Lunes 8 de abril a las 16hs - Seminarios DQIAQF - INQUIMAE]

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Seminarios DQIAQF – INQUIMAE -  Lunes 8 de abril a las 16hs.

Aula de Seminarios INQUIMAE - DQIAQF
Facultad de Ciencias Exactas y Naturales
Ciudad Universitaria - Pab. 2  -  Piso 3


“Investigating the fine coupling between neuronal activity and blood supply
in brain”

*CHRISTIAN AMATORE*
Ecole Normale Supérieure, UPMC & CNRS. Département de Chimie
24 rue Lhomond, 75231 Paris Cedex 05, France
*http://129.199.32.32./w3amatore/index_angl.html/*


Oxidative stress damages are reputed to be important causative factors in
several human pathologies (DNA alteration, aging, several cancers, AIDS,
Parkinson and Alzheimer diseases, etc.). Yet, oxidative stress is also used
positively by living organisms. However, investigations of the primary
effect of oxidative stress machinery remained for long impossible because
of the lack of adequate analytical methods able to detect and analyze the
release of few femtomoles of very reactive species.
Using platinized carbon fiber ultramicroelectrodes positioned in the
“artificial synapse” configuration we have been able to investigate
quantitatively these phenomena and demonstrate in particular that there are
essential in controlling the activity of the brain through modulation of
local hyperemia, i.e., of the fine regulating process through which our
brains may provide sufficient blood to neurons in active state without
risking overpressure. In fact this mechanism is the very fundamental one
which allows today neuroscientists and medical doctors to investigate the
brain activity for medical purposes or cognitive sciences through using
functional MRI or PET-scan imaging.