[Todos] Coloquios DF: J. Albino Aguiar (UFP) Jueves 24/10, 14hs, Aula Seminario, 2do piso, Pab. I

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COLOQUIOS DEL DEPARTAMENTO DE FÍSICA FCEYN - UBA

           En el Aula Seminario, 2do piso, Pab. I, 

           Jueves 24/10, 14hs:

           J. ALBINO AGUIAR

           Dto Fisica, Universidade Federal de Pernambuco

          
          MAGNETIC NANOPARTICLES FOR NANOMEDICINE APPLICATIONS

    

In the recent years, superparamagnetic nanoparticles have been widely used
in biology and medicine for different purposes, such as protein and enzyme
immobilization, bio-separation, immunoassays, hyperthermia, drug delivery,
magnetically enhanced transfection, tissue engineering and MRI. Typically,
for biomedical purposes, MNPs are often surface-coated in order to improve
their stability and biocompatibility, and to achieve hydrophilicity and
conjugating capability. Several coating materials have been used to modify
the surface chemistry of the MNPs, including organic polymers (e.g.
dextran, chitosan, polyethylene glycol), organic surfactants (e.g. sodium
oleate and dodecylamine), inorganic metals (e.g. gold), inorganic oxides
(e.g. silica and carbon) and bioactive molecules and structures (e.g.
liposomes, peptides and ligands/receptors).

Magnetic nanoparticles (MNPs) can be manipulated under the influence of an
external magnetic field. They are usually composed of magnetic elements,
such as iron, nickel, cobalt and their respective oxides. In contrast to
bulk magnetic materials whose magnetic properties are influenced by the
thermal motion between magnetic domains, magnetic nanoparticles show single
magnetic domains with all the spins aligned. There is no magnetization
interference between domain walls in the MNPs as in the case of bulk
materials. Therefore, due to their size, MNPs exhibit different electrical,
chemical, magnetic and optical properties than in bulk size.

Iron oxides, such as magnetite (Fe3O4), are commonly used for the
synthesis of magnetic nanoparticle. They present stable magnetic response,
are biodegradable, biocompatible, and present superparamagnetic effects on
magnetic resonance imaging (MRI).

In this talk we will present result on the preparation, structural,
microstructural and magnetic characterization as well as on the application
of magnetic uncoated and fucan-coated and nanoparticles for enzyme
immobilization and cancer treatment.

    
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