[Todos] SEMINARIO EXTRAORDINARIO QB 2014 - Martes 30 de septiembre 11 h - Martín Crespi

[Claudia Sepúlveda]

SEMINARIO EXTRAORDINARIO DEL DEPARTAMENTO DE QUÍMICA BIOLÓGICA

MARTES 30 de septiembre a las 11:00 h, Aula Cardini del Departamento de
Química Biológica, 4to piso.
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Expositor: Martín Crespi PhD
CNRS, Institut des Sciences du Végétal, Université Paris-Diderot, Sorbonne
Paris Cité, SPS Saclay Plant Sciences, 91198 Gif-sur-Yvette, France Unité
de recherche en Génomique Végétale, UMR INRA-UEVE, Evry, France

"Long non-coding RNAs in epigenetic and splicing regulation of root
development."

Non-protein coding RNAs (npcRNA) represent an emerging class of
riboregulators, which act either directly in a long form or are processed
to shorter miRNA and siRNAs. Plant and animals use long and small ncRNAs
for post-transcriptional mRNA and epigenetic regulations. We have
performed genome-wide bioinformatic analysis of transcriptomic databases
and identified many Arabidopsis long npcRNAs. Eleven npcRNAs were
antisense to protein-coding mRNAs whereas certain corresponded to miRNA or
siRNA precursors. The expression pattern of long npcRNAs in response to
phytohormones and environmental stresses suggested a link with root growth
and development. Interestingly, certain 24nt siRNAs derived from the long
npcRNA APOLO which is close to the PID regulatory gene controlling auxin
responses. An epigenetic link between specific npcRNAs, chromatin loop
dynamics and PID relation in roots could be established. Another npcRNA
interacted with a specific RNA binding protein revealing unexpected
relationships with alternative splicing during auxin-mediated regulation
of root development. Indeed, this npcRNA modulates the action of a novel
alternative splicing regulator on its specific mRNA targets. Long and
small npcRNAs may fine tune expression patterns of regulatory genes
through interactions with RBPs to modulate root development and its
plasticity in response to the soil environment.
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Los esperamos!

Martín Edreira
Diego Grinman
Diego Laderach
Claudia Sepúlveda

Organizadores de los Seminarios del Dpto. Química Biológica, FCEyN-UBA.


Puede consultarse la agenda de próximos seminarios en
http://www.qb.fcen.uba.ar/seminarios.htm