[Todos] coloquio extraordinario QB-DF Aleksandra Walczak

[Ariel Chernomoretz]

Estimados,

Este próximo viernes 26-10 se llevará a cabo un Seminario extraordinario
en el Departamento de Química Biológica de la FCEN, UBA.

Estara a cargo de la Dra. Aleksandra M. Walczak del Physique Théorique
Ecole Normale Supérieure, Paris, Francia, que desde hace tiempo  
utiliza modelos de la mecanica estadista para caracterizar y estudiar  
el funcionamiento del sistema inmune: es decir, como sistemas  
biologicos son capaces de reconocer y destruir organismos patogenos.


Título: "Diversity and Response in Immune Repertoires"

Abstract:
The diversity of repertoires of B-cell and T-cell receptors is
generated by a stochastic process of gene rearrangement called VDJ
recombination, and is later sculpted by selection, clonal
proliferation, and somatic hypermutations. I will show how these
processes can be learned quantitatively from high-throughput
repertoire sequencing data. The resulting models can then be used to
estimate the diversity of repertoires and their overlap between
individuals, to identify condition-specific immune receptors from
patient cohort data, and to detect signatures of immune responses in
single patients, opening the way for novel sequencing-based diagnostic
and prognostic tools.

Horario 12:30-14hs   Aula Cardini   4to Piso
Departamento de Química Biológica, Facultad de Ciencias Exactas y
Naturales,UBA. Pabellón 2.

Saludos
Ariel.