[Todos] Two post-doctoral positions available at the Candiolo Cancer Institute FPO-IRCCS (Turin, Italy)

[Manuel Saenz]

Les reenvío esta búsqueda que me llegó.

Salù.

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Dear All,

We are pleased to inform you that

*Two postdoctoral positions* are available in the Cell Migration
laboratory in the Candiolo Cancer Institute FPO-IRCCS (Turin, Italy).

The research project is focused on *patient-derived tumor organoids* as
realistic tumor models that are amenable to single-cell level live
observations. We propose to exploit (i) *single-cell RNAseq* technology
to describe populations in untreated and treated organoids; (ii)
*imaging*based lineage-tracing experiments that will allow to track
single cells belonging to different subpopulations and their fates in
terms of proliferation/apoptotic rates and differentiation into other
subtypes; (iii) *mathematical population models* to integrate all the
experimental data into a comprehensive falsifiable model.

We are seeking for motivated young candidates that are willing to
perform research by interacting with a multidisciplinary environment.
The salary and duration of research fellowship will be adjusted to the
applicant’s profile.

*Profile 1 *

The candidate should ideally be with a *quantitative background*, i.e.
master’s degree and PhD in Physics, Computer Science or Applied
Mathematics with experience in computational tools, programming
languages, data analysis.The research activity of the project will involve

1. quantitative image analysis pipeline development, maintenance and use
to perform data analysis on imaging experiments 2. bioinformatic
analysis on scRNAseq datasets. 3. mathematical modeling and numerical
simulations.

It will be crucial for the candidate to have previous experience with
numerics/computational data analysis with Python, Matlab, R or other
programming languages and similar tools. Overall a motivation for
multidisciplinarity, strong computational skills and ability to work in
a team will be the most important desired qualifications of the
applicant. Previous experience with biology projects, willingness to
perform imaging experiments and/or simple wet lab tasks, previous
knowledge of image analysis will all be a plus.

Applicants for this profile should send their interest in the
application to _alberto.puliafito en ircc.it
<https://webmail.ictp.it/webmail/src/compose.php?send_to=alberto.puliafito%40ircc.it>_.

**

*Profile 2 *

The candidate should ideally be with a *life science background*, i.e.
master’s degree and PhD in Biology, Biotechnology or equivalent
biomedical degree with previous experience in cell culture techniques
and molecular biology.

The research activity of the project will involve
1. maintenance of
organoids cultures
2. live microscopy experiments both confocal and
widefield
3. design and use of fluorescent reporters, lentiviral vector
preparation, organoid infection/transfection 4. scRNAseq experiments on
organoids

It will be crucial for the candidate to have previous experience with
imaging, either confocal or widefield. Overall a motivation for
multidisciplinarity, strong molecular biology skills and ability to work
in a team will be the most important desired qualifications of the
applicant. Previous experience with 3D cultures, image analysis, and
live imaging will all be a plus.

Applicants for this profile should send their interest in the
application to _luca.primo en ircc.it
<https://webmail.ictp.it/webmail/src/compose.php?send_to=luca.primo%40ircc.it>_.


Please circulate this announcement to anyone interested.


Thanks


Barbara Valassi for QLS Section
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