[Todos] HOY MARTES 14:30 Peter Wolynes en pabII

[ferreiro en qb.fcen.uba.ar]

Martes 12 de octubre a las 14:30 hs, Aula de SEMINARIOS del Departamento
de Química Biológica, 4to piso Pab II
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Dr. Peter G. Wolynes
University of California, San Diego

"Recent Successes of the Energy Landscape Theory of Protein Folding"

Protein folding can be understood as a biased search on a funneled but
rugged energy landscape. This picture can be made quantitative using the
statistical mechanics of glasses and first order transitions in mesoscopic
systems. The funneled nature of the protein energy
landscape is a consequence of natural selection. I will discuss how this
rather simple picture quantitatively predicts folding mechanism from
native structure and sequence. Recent advances using the energy landscape
ideas to design algorithms to predict protein structure from sequence
will also be reviewed.

wolynes.ucsd.edu