[Todos] Seminarios conjuntos IFIBYNE-DFBMC- Jueves 22/9 - Dr. Gregory Quirk

[Paula Felman]

Jueves 22 de septiembre 13 Hs. en el aula de seminarios.

Dr. Gregory Quirk

Título: "Prefrontal control of fear and extinction: The view from Puerto Rico"

Our lab studies the mechanisms of emotional 
regulation using extinction of conditioned fear. 
Much of what is known about extinction comes from 
animal models using Pavlovian fear conditioning. 
We found that a subregion of the prefrontal 
cortex, the infralimbic cortex (IL), is necessary 
for extinction (fear inhibition). Moreover, we 
found that another mPFC subregion, the prelimbic 
cortex (PL), is necessary for fear expression. We 
suggest that IL inhibits fear by inhibiting 
amygdala output, whereas PL drives fear by 
increasing amygdala output. In addition to our 
rat studies, we are now studying fear in humans, 
with the goal of developing new treatments for anxiety disorders.

Host: Mariana Feld