[Todos] Recordatorio HOY: Seminarios conjuntos IFIBYNE-DFBMC - HOY Jueves 20/12 - Manuel de la Mata, PhD.

[Petry]

*Jueves 20 de diciembre 13 Hs. en el aula de seminarios del IFIBYNE.*


 Título: Mechanistic aspects of miRNA turnover in neurons

 Manuel de la Mata, PhD. Friedrich Miescher Institute for Biomedical
Research
 Basel, Switzerland


 Abstract: Increasing evidence indicates that the development and function
of the nervous system is dependent on the spatiotemporal expression of a
wide repertoire of microRNAs. In dendrites of mature neurons, local
post-synaptic translation seems to have a particularly important role in
synaptic plasticity and memory. MicroRNAs have been shown to regulate local
protein translation at neuronal dendrites, but little is known about its
mechanism and functional relevance. Intriguingly, the turnover of microRNAs
is greatly accelerated in neurons relative to most cell types, and this
property is dependent on neuron activity. Here we investigate the role of
target mRNAs in reciprocally regulating microRNA degradation in neurons.
Whereas canonically, microRNAs silence their target mRNAs, recent reports
show that target mRNAs may in turn influence the decay of their cognate
microRNAs. We propose that in neurons, where the mutual regulation between
microRNAs and their targets has not yet been explored, this mechanism might
be important for role of microRNAs in neuronal functions.

 Host: ARK




--Ezequiel Petrillo
Laboratorio de Fisiología y Biología Molecular
Facultad de Ciencias Exactas y Naturales
Universidad de Buenos Aires
Ciudad Universitaria - Pabellón 2 - 2º piso
(C1428EHA) Buenos Aires - Argentina
Tel: 54-11-4576-3386 /4576-3368 interno 116
FAX: 54-11-4576-3321
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