[Todos] HOY: Coloquio - Carlos Bustamante - Power at the Nanoscale: Speed, Strength and Efficiency in Biological Motors

[Coloquios DF-Exactas UBA]

*Jueves 15 de abril 2021 a las 14hs*
Coloquio del Departamento de Física - Exactas - UBA

*Power at the Nanoscale: Speed, Strength and Efficiency in Biological
Motors*
*Carlos Bustamante - University of California, Berkeley*
Many cellular processes are performed by highly specialized and evolved
entities that function as molecular machines. Some of these protein
machines operate cyclically converting chemical energy into mechanical work
through the generation of force or torque and displacement. These machines
are referred to as “molecular motors”. I will give examples of several
molecular motors in the cell, as well as their classification in terms of
their mode of operation. The mechanical paradigm in biology is not new; as
I will show, these ideas have been around since the XVII century, but our
understanding of their operation has increased enormously through the use
of single molecule manipulation methods and of modern biophysical
techniques such as optical tweezers. I will describe some of our recent
results in the study of the DNA packaging motor of bacteriophage Phi29,
including its impressive thermodynamic efficiency. This is a feature that
is common to many motors of biological origin. I will then speculate about
the possible origin of this energetic efficiency based on recent results
about energy dissipation. I will end by describing the impressive
coordination among the different parts of the packaging motor using
high-spatial resolution optical tweezers.



Asistí via youtube: https://youtu.be/CFCiwkfFfY4
o via Zoom:
https://exactas-uba.zoom.us/j/86058464409?pwd=dnpXK1lDOEQrWER1TEd4RnZURHAvQT09
ID de reunión: 860 5846 4409 Código de acceso: 904962

[image: bustamante.png]
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